Significance thresholds for QTL interval mapping tests
نویسندگان
چکیده
منابع مشابه
Approximate thresholds of interval mapping tests for QTL detection.
A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these thresholds for backcross, recombinant inbreds and F2 for any given level and any...
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In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.
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QTL hotspots (genomic locations affecting many traits) are a common feature in genetical genomics studies, and are biologically interesting since they may harbor critical regulators. Therefore, statistical procedures to assess the significance of hotspots are of key importance. One approach, randomly allocating observed QTLs across the genomic locations separately by trait, implicitly assumes a...
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ژورنال
عنوان ژورنال: Heredity
سال: 1996
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.1996.68